1-(isopropylamino)-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]propan-2-ol hydrochloride

Name	1-(isopropylamino)-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]propan-2-ol hydrochloride
Synonyms	SL 75212 BETAXOLOL HCL BETAXOLOL CHLOROHYDRATE Betaxolol Hydrochloride BETAXOLOL HYDROCHLORIDE BETAXOLOL HYDROCHLORIDE MONOHYDRATE (+-)-1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propano 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-isopropylaminopropan-2-olhydroc 1-[4-[2-(CYCLOPROPYLMETHOXY)ETHYL]PHENOXY]-3-ISOPROPYLAMINO-2-PROPANOL HYDROCHLORIDE 1-(isopropylamino)-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]propan-2-ol hydrochloride
CAS	63659-19-8
EINECS	264-384-3
InChI	InChI=1/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H

Molecular Formula	C18H30ClNO3
Molar Mass	343.89
Melting Point	116°
Boling Point	448°C at 760 mmHg
Flash Point	224.7°C
Solubility	H2O: 36mg/mL, soluble
Vapor Presure	8.26E-09mmHg at 25°C
Appearance	solid
Color	white
Merck	14,1182
Storage Condition	2-8°C
In vitro study	Betaxolol protects retinal neurons. Betaxolol attenuates NMDA induction when β-adrenoceptor agonists are ineffective. Glutamate-induced LDH release was essentially completely blocked by the addition of Betaxolol (10 μm). Betaxolol (100 μm) is effective in preventing the release of LDH in cortical tissue caused by hypoxia.
In vivo study	Changes in calreticulin and ChAT immunoreactivity were reduced and the B- wave was prevented by intraperitoneal injection of Betaxolol before regional anemia and reperfusion injury in rats. The inclusion of Betaxolol can partially block the changes caused by NMDA and hypoxia/glucose.

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
WGK Germany	3
RTECS	UA9823000
HS Code	2922504500
Toxicity	LD50 in mice (mg/kg): 944 orally; 37 i.v. (Manoury)

Update Date:	2022/11/12 10:05:38
biological activity	Betaxolol (SL 75212) is a beta 1 adrenergic receptor blocker with an IC50 of 6 m.
Target	Value
β1-adrenergic receptor	6 μM

Last Update：2024-04-09 19:05:13

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CAS: 63659-19-8
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1-(isopropylamino)-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]propan-2-ol hydrochloride Request for Quotation